Clinical Trials

The Office of Research at Saint Peter’s University Hospital is currently managing over 100 different clinical studies.  Of these, here is a sampling of some of the groundbreaking trials that are currently enrolling new patients:
 
Division COORD. SPONSOR PROTOCOL# STUDY TITLE
Adult Oncology Vazquez-Telewoda, Kimberly BTG International TheraSphere Humanitarian Device A Humanitarian Device Exemption use Protocol of TheraSphere For Treatment of Unresectable Primary or Secondary Liver Cancer
Adult Oncology Drost, Charlene Celgene Corporation MDS/AML Connect MDS/AML Disease Registry
Adult Oncology Vazquez-Telewoda, Kimberly Juno Therapeutics 017006 A Phase 2 Study of Lisocabtagene Maraleucel (JCAR017) as Second-Line Therapy in Adult Patients with Aggressive B-cell NHL (017006)
Adult Oncology Vazquez-Telewoda, Kimberly Juno Therapeutics 017007 A Safety Trial of Lisocabtagene Maraleucel (JCAR017) for Relapsed and Refractory (R/R) B-cell Non-Hodgkin Lymphoma (NHL) in the Outpatient Setting
Adult Oncology Vazquez-Telewoda, Kimberly Precision Rad/Onc Lung Immunotherapy A Prospective Trial Of Immunotherapy And Stereotactic Body Radiotherapy (Sbrt) For The Treatment Of Metastatic Lung Cancer: Sbrt Sensitization Of The Programmed Death-1 (Pd-1) Effect
Adult Oncology Vazquez-Telewoda, Kimberly Seer, Inc. 020102 (SEERPRO) SEERPRO: A Prospective Blood Sample Collection Study to Evaluate A Panel of Protein-based Biomarkers
Adult Oncology Vazquez-Telewoda, Kimberly SPUH Medactionplan Pro (Map Pro) Integration Of A Comprehensive Medication Management System Called Medactionplan Pro (Map Pro) To Improve Patient Safety And Adherence Of Medication Therapy In The Outpatient Cancer Center At Saint Peter’s University Hospital
Breast Surgery Vazquez-Telewoda, Kimberly Alliance A011401 Randomized trial evaluating the role of weight loss in adjuvant treatment of overweight and obese women with early breast cancer
Breast Surgery Vazquez-Telewoda, Kimberly Caris Life Sciences TCBIO-001-0710 The Caris Biorepository Research Protocol
Breast Surgery Vazquez-Telewoda, Kimberly ECOG EA1151 Tomosynthesis Mammographic Imaging Screening Trial (TMIST)
Breast Surgery Vazquez-Telewoda, Kimberly NRG BR003 Randomized trial of adjuvant therapy comparing doxorubicin plus cyclophosphamide followed by weekly paclitaxel with or without carboplatin for node positive or high risk node negative triple negative invasive breast cancer
Dept. of Anesthesiology Drost, Charlene SPUH Continuous Electronic Monitoring Prevention and Detection of Respiratory Depression Associated with Administration of Neuraxial Morphine for Cesarean: The Role of continuous Electronic Monitoring
Dept. of Medicine   AbbVie M20-404 A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Single Ascending Doses of ABBV-47D11 in Adults Hospitalized with COVID-19
Dept. of Medicine Vazquez-Telewoda, Kimberly Chiesi Therapeutics CUSA-081-HEM-01 (READY 1) A Phase 3, Randomized, Double-Blind, Active And Placebo-Controlled Sudy On The Use Of Cusa-081for Dysfunctional Central Venous Access Devices (Cv Ads)
Dept. of Medicine   SPUH Early Markers Autism Development of Early Markers of Autism Spectrum Disorder (ASD)
Dept. of Medicine Vazquez-Telewoda, Kimberly SPUH Biomarkers in COVID-19 Clinical, Biochemical, and Immune Biomarkers in COVID-19: A Natural History Study
Dept. of Medicine   SPUH Naptime Sleep Protocol Naptime Sleep Protocol
Dept. of Surgery Zanko, Joanna SPUH Nanoparticle Targeted Chemo Molecularly Defined Dendritic Polypeptide Nanoparticle-based Targeted Delivery of Chemotherapy
Genetics & Genomic Medicine Silva, Daniela Genzyme 10-090 Gaucher MAIN and Pregnancy Sub-Registry 10-090 Gaucher MAIN and Pregnancy Sub-Registry
Genetics & Genomic Medicine Silva, Daniela Genzyme 10-091 Fabry MAIN and Pregnancy Sub-Registry 10-091 Fabry MAIN and Pregnancy Sub-Registry
Genetics & Genomic Medicine Silva, Daniela Genzyme 10-092 MPSI MAIN and Pregnancy Sub-Registry 10-092 MPSI MAIN and Pregnancy Sub-Registry
Genetics & Genomic Medicine Silva, Daniela Genzyme 10-093 Pompe MAIN and Pregnancy Sub-Registry 10-093 Pompe MAIN and Pregnancy Sub-Registry
Genetics & Genomic Medicine Silva, Daniela Passage Bio, Inc. PBGM01-001 A Phase 1/2 Open-Label, Multicenter, Dose Ranging and Confirmatory Study to Assess the Safety, Tolerability and Efficacy of Single Dose of PBGM01 Delivered into the Cisterna Magna of Pediatric Subjects Aged 1 to 24 Months with Type 1 (Infantile) and Type 2a (Late Infantile) GM1 Gangliosidosis
Genetics & Genomic Medicine Silva, Daniela SPUH SPUH - Regional Center for Newborn Screening & Gen Newborn Screening and Genetic ServicesDFHS17NWB01246.02008
Maternal Fetal Medicine Beche, Imene Columbia University ALPS FSP (AAAR5624) Childhood Pulmonary Complication
Maternal Fetal Medicine Beche, Imene Columbia University ALPS Neuro (AAAR5971) Childhood Cognitive Function in a birth cohort after a randomized trial of antenatal corticosteroids: The ALPS Neurocognitive follow up study.NIH
Maternal Fetal Medicine Beche, Imene Columbia University AWARE (AAAS3077) Activity in Women at Risk for Early delivery (AWARE) An Ancillary Study
Maternal Fetal Medicine Otarola, Sol Columbia University ECCHO-NFGS (AAAR4976) Environmental Contributors to Child Health Originating from the National Fetal Growth Study (ECCHO-NFGS)
Maternal Fetal Medicine Perez, Clara Columbia University Exosome CMV/Zika (AAAR7108) Maternal Plasma Exosome Testing to Detect Fetal Brain Injury Following CMV or Zika Infection
Maternal Fetal Medicine Beche, Imene Columbia University PROSPECT A randomized trial of Pessary and Progesterone for Pretern Prevention in Twin Gestation with a short cervix
Maternal Fetal Medicine Bergman, Anne Columbia University SLEEP CPAP (AAAR8244) A Randomized Trial of Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy (SLEEP)
Maternal Fetal Medicine Beche, Imene Columbia University The CPR Study Cholestasis of pregnancy and the PR interval: the CPR study
Maternal Fetal Medicine Otarola, Sol Columbia University TOPS (AAAR1388) A Randomized trial of pessary in singleton pregnancies with a short cervix
Maternal Fetal Medicine Perez, Clara Columbia University TXA (AAAR6736) Tranexamic Acid for the prevention of obstetrical hemorrhage after cesarean delivery: A Randomized Controlled Trial
Maternal Fetal Medicine Perez, Clara Columbia University PACT Prescription After Cesarean Trial (PACT)
Maternal Fetal Medicine Beche, Imene Illumina NIPT-C00-002 (Denali) Prospective Collection of Whole Blood Specimens From Pregnant Women at Any Risk of Fetal Chromosomal Anomaly for the Development of a Noninvasive Prenatal Test
Maternal Fetal Medicine Beche, Imene Illumina RGH-014 (AAAR0695) Prospective Collection of Blood Specimens in Pregnant Women Diagnosed with Preterm Preeclampsia and/or Fetal Growth Restriction in Support of Molecular Assay Development
Maternal Fetal Medicine Otarola, Sol Natera 14-024-NPT (SMART) SNP-based Microdeletion and Aneuploidy RegisTry (SMART) (SMART)
Maternal Fetal Medicine Perez, Clara National Institute Of Health HCV study An Observational Study of Hepatitis C Virus in Pregancy
Maternal Fetal Medicine Sklios, Molly NICHD MFMU COVID-19 Maternal Morbidity and Mortality During during the COVID-19 Pandemic
Maternal Fetal Medicine Perez, Clara NICHD CMV Study A Randomized Trial to Prevent congenital cytomegalovirus infection CMV
Maternal Fetal Medicine Perez, Clara NICHD Pravastatin Preeclampsia A Randomized Controlled Trial of Pravastatin to Prevent Preeclampsia in High Risk Women
Maternal Fetal Medicine Otarola, Sol Pfizer C3671008 A Phase 3, Randomized, Double- Or Observer-Blinded, Placebo-Controlled Trial To Evaluate The Efficacy And Safety Of A Respiratory Syncytial Virus (Rsv) Prefusion F Subunit Vaccine In Infants Born To Women Vaccinated During Pregnancy
Maternal Fetal Medicine Perez, Clara Rutgers University PRN Collaboration (AAAR1870) Does the Cerebroplacental Ratio (CPR) Predict Adverse Outcomes in Low Risk Pregnancies? (CPR)RU010312017
Maternal Fetal Medicine Beche, Imene Sequenom Inc SQNM-T21-107 Collection of Whole Blood Specimens from Pregnant Women at Increased Risk for Fetal Chromosomal Abnormality for use in Development of a Noninvasive Prenatal Test in the Detection of the Relative Quantity of Chromosomal Material in Circulating Cell-Free DNA Extracted from Maternal Plasma
Maternal Fetal Medicine Beche, Imene University of Alabama at Birmingham CHAP Chronic hypertension and Pregnancy Project (CHAP)1U01HL119242-01
Maternal Fetal Medicine Otarola, Sol University of North Carolina MOMPOD Medical Optimization and Management of Pregnancies with Overt Type 2 Diabetes (MOMPOD) Study5R01HD086139-025109533
OB/GYN Moser, Barbara SPUH Peri Cleansing Protocol Peri Cleansing Protocol for the Laboring Patient to Prevent Chorioamniotis: A Randomized Controlled Trial (PCP)
Pediatric Infectious Diseases Drost, Charlene University of Alabama at Birmingham DMID 19-0005 A Prospective Study Of Acute Flaccid Myelitis (Afm) To Define Natural History, Risk Factors, And Pathogenetic Mechanisms
Pediatric Infectious Diseases Drost, Charlene University of Alabama at Birmingham DMID 19-0026 Neonatal Enterovirus and Human Parechovirus Viral Sepsis: Natural History and Predictors of Morbidity and Mortality
Pediatric Neurology McMahan, Shona Aquestive (MonoSol) 160325 A Multicenter, Open Label, Cross-Over Study to Assess the Pharmacokinetics and Safety of Diazepam Buccal Soluble Film (DBSF) in Pediatric Subjects with Epilepsy
Pediatric Neurology McMahan, Shona Aquestive (MonoSol) 42-1703 An Open-Label, Safety and Tolerability Study of Chronic Intermittent Use of Diazepam Buccal Soluble Film (DBSF) in Pediatric, Adolescent and Adult Subjects With Epilepsy
Pediatric Neurology McMahan, Shona Eisai Inc. E2007-G000-238 An Open-Label Study With an Extension Phase to Evaluate the Pharmacokinetics of Perampanel (E2007) Oral Suspension When Given as an Adjunctive Therapy in Subjects From 1 Month to Less Than 4 Years of Age With Epilepsy
Pediatric Neurology McMahan, Shona Eisai Inc. E2007-G000-338 A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial With an Open-Label Extension Phase of Perampanel as Adjunctive Treatment in Subjects at Least 2 Years of Age With Inadequately Controlled Seizures Associated With Lennox-Gastaut Syndrome
Pediatric Neurology McMahan, Shona Ovid Therapeutics TAK-935-18-001 (OV935) A Phase 2, Prospective, Interventional, Open-Label, Multi-Site, Extension Study To Assess The Long-Term Safety And Tolerability Of Tak-935 As Adjunctive Therapy In Patients With Rare Epilepsy
Pediatric Neurology McMahan, Shona Ovid Therapeutics TAK-935-2002 (ELEKTRA) A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study To Evaluate The Efficacy, Safety, And Tolerability Of Tak-935 As An Adjunctive Therapy In Pediatric Patients With Developmental And/Or Epileptic Encephalopathies
Pediatric Neurology Vazquez-Telewoda, Kimberly Teva Pharmaceuticals TV50717-CNS-30080 A Randomized, Double-Blind, Placebo-Controlled Study of TEV-50717 (Deutetrabenazine) for the Treatment of Dyskinesia in Cerebral Palsy in Children and Adolescents
Pediatric Neurology McMahan, Shona Teva Pharmaceuticals TV48125-CNS-30082 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Comparing the Efficacy, Safety, and Tolerability of Subcutaneous Administration of Fremanezumab Versus Placebo for the Preventive Treatment of Chronic Migraine in Pediatric Patients 6 to 17 Years of Age
Pediatric Neurology McMahan, Shona Teva Pharmaceuticals TV48125-CNS-30083 A Multicenter, Open-Label Study Evaluating the Long-Term Safety, Tolerability, and Efficacy of Monthly Subcutaneous Administration of Fremanezumab for the Preventive Treatment of Episodic and Chronic Migraine in Pediatric Patients 6 to 17 Years of Age
Pediatric Neurology McMahan, Shona Teva Pharmaceuticals TV48125-CNS-30084 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Comparing the Efficacy, Safety, and Tolerability of Subcutaneous Administration of Fremanezumab Versus Placebo for the Preventive Treatment of Episodic Migraine in Pediatric Patients 6 to 17 Years of Age
Pediatric Neurology McMahan, Shona Teva Pharmaceuticals TV50717-CNS-30081 An Open Label, Long Term Safety, Tolerability and Efficacy Study of TEV-50717 (Deutetrabenazine) for the Treatment of Dyskinesia in Cerebral Palsy in Children and Adolescents
Pediatric Neurology McMahan, Shona UCB Biosciences EP0065 A Multicenter, Open-Label Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Intravenous Brivaracetam In Subjects =1 Month To <16 Years Of Age With Epilepsy
Pediatric Neurology McMahan, Shona UCB Biosciences N01266 Open-Label, Single-Arm, Multicenter, Long-Term Follow-Up Study To Evaluate Safety And Efficacy Of Brivaracetam Used As Adjunctive Treatment In Pediatric Subjects With Epilepsy
Pediatric Neurology McMahan, Shona UCB Biosciences EP0093 An Open-Label, Multicenter, Extension Study To Evaluate The Safety And Efficacy Of Padsevonil As Adjunctive Treatment Of Focal-Onset Seizures In Adult Subjects With Drug-Resistant Epilepsy
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) AALL1631 International Phase 3 trial in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) testing imatinib in combination with two different cytotoxic chemotherapy backbones
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) AALL1731 A Phase 3 Trial Investigating Blinatumomab (IND# 117467, NSC# 765986) in Combination with Chemotherapy in Patients with Newly Diagnosed Standard Risk or Down syndrome B-Lymphoblastic Leukemia (B-ALL) and the Treatment of Patients with Localized B-Lymphoblastic Lymphoma (B-LLy)
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) AALL1732 A Phase 3 Randomized Trial of Inotuzumab Ozogamicin (IND#:133494, NSC#: 772518) for Newly Diagnosed High-Risk B-ALL; Risk-Adapted Post-Induction Therapy for High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and Disseminated B-LLy
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) ACNS1422 Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) ACNS1721 A Phase 2 Study of Veliparib (ABT-888, IND# 139199) and Local Irradiation, Followed by Maintenance Veliparib and Temozolomide, in Patients with Newly Diagnosed High-Grade Glioma (HGG) without H3 K27M or BRAFV600E Mutations
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) AGCT1532 (ANZUP 1302) A randomised phase 3 trial of accelerated versus standard BEP chemotherapy for patients with intermediate and poor-risk metastatic germ cell tumours
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) ALTE03N1 Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) ALTE05N1 Umbrella Long-Term Follow-Up of Patients Who Have Participated in Children's Oncology Group Studies
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) ANBL00B1 Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) ANBL1232 Utilizing Response- and Biology-Based Risk Factors to Guide Therapy in Patients with Non-High-Risk Neuroblastoma
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) APEC14B1 EveryChild A Registry, Eligibility Screening, Biology and Outcome Study
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) APEC1621A Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions (A Pediatric MATCH Treatment Trial)
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) APEC1621B Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial)
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) APEC1621D PI3K/mTOR Inhibitor LY3023414 in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial)
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) APEC1621F Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With ALK or ROS1 Genomic Alterations (A Pediatric MATCH Treatment Trial)
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) APEC1621G Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations (A Pediatric MATCH Treatment Trial)
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) APEC1621H Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Defects in DNA Damage Repair Genes (A Pediatric MATCH Treatment Trial)
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) APEC1621SC (MATCH) Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) AREN03B2 Renal Tumors Classification, Biology, and Banking Study
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) ARST1431 A Randomized Phase 3 Study of Vincristine, Dactinomycin, Cyclophosphamide (VAC) Alternating with Vincristine and Irinotecan (VI) Versus VAC/VI Plus Temsirolimus (TORI, Torisel, NSC# 683864) in Patients with Intermediate Risk (IR) Rhabdomyosarcoma (RMS)
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) AALL15P1 Azacitidine and Combination Chemotherapy in Treating Infants With Acute Lymphoblastic Leukemia and KMT2A Gene Rearrangement
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) AALL1621 A Phase 2 Study of Inotuzumab Ozogamicin (NSC# 772518, IND# 133494) in Children and Young Adults with Relapsed or Refractory CD22+ B-Acute Lymphoblastic Leukemia (B-ALL)
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) AEWS1221 Randomized Phase 3 Trial Evaluating the Addition of the IGF-1R Monoclonal Antibody Ganitumab (AMG 479, NSC# 750008, IND# 120449) to Multiagent Chemotherapy for Patients with Newly Diagnosed Metastatic Ewing Sarcoma
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) AHOD1331 A Randomized Phase III Study of Brentuximab Vedotin Newly Diagnosed High-Risk Classical Hodgkin Lymphoma in Children and Adolescents
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) APEC1621C Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial)
Pediatric Oncology Zaidi, Naureen Childrens Oncology Group (COG) APEC11621E Selumetinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial)
Pediatrics   SPUH Biomarker Memory in ASD Biomarkers of Innate Immune Memory in Autism Spectrum DisordersNJ Gov Council Grant
Radiation Oncology Vazquez-Telewoda, Kimberly Alliance A011502 A Randomized Phase Iii Double Blinded Placebo Controlled Trial Of Aspirin As Adjuvant Therapy For Her2 Negative Breast Cancer: The Abc Trial
Radiation Oncology Vazquez-Telewoda, Kimberly Alliance DCP-001 Use of a Clinical Trial Screening Tool to Address Cancer Health Disparities in the NCI Community Oncology Research Program (NCORP)
Radiation Oncology Vazquez-Telewoda, Kimberly CCTG MA.39 (Tailor RT) Tailor RT: A Randomized Trial of Regional Radiotherapy in Biomarker Low Risk Node Positive Breast Cancer(CCTGMA.39)
Radiation Oncology Vazquez-Telewoda, Kimberly Crozer-Keystone Health Systems CK-DESPOT CyberKnife Dose Escalation Prostate Cancer Trial (CK-DESPOT)
Radiation Oncology Vazquez-Telewoda, Kimberly Radiosurgery Society RSSearch Patient Registry RSSearch Patient Registry for Patients who may be Treated with Radiosurgery at Saint Peter's University Hospital
Radiation Oncology Vazquez-Telewoda, Kimberly SPUH Breast Cyberknife A Pilot Study of Partial Breast CyberKnife® for Postmenopausal Women 50 Years of Age or Older with DCIS or Stage I Breast Cancer
Radiation Oncology Vazquez-Telewoda, Kimberly SPUH Lung Cancer Registry Lung cancer registry study - Cyberknife® Radiosurgery VS external beam radiation therapy

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